Isoquinoline alkaloids in small domestic animals
Polyfunctionality of the use of isoquinoline alkaloids in the complex therapy of small domestic animals.
The growing incidence of atopic dermatitis, as well as idiopathic enteritis, confuses many veterinary specialists because traditional therapy does not have the desired effect. The situation is aggravated by the situation in which most of the urban domestic animals are kept: regular contact with reagents, unusual food sources, as well as regular stresses.
Therefore, the relevance of the use of alternative means in veterinary medicine is not in doubt.
Currently, probiotic supplements have found widespread use in veterinary medicine for small domestic animals, but they are not able to fight pathogenic microflora in the conditions of an already occurring pathological process.
During the study, it was decided to divide animals into groups of pathologies (inflammatory processes in the gastrointestinal tract and skin lesions of various etiologies) in order to apply the supplement per os and ad usum externum (Sol. Sangroviti), respectively.
An additive with an alkaloid content of 2% was used in the following dosages: for watering 1 gram per head per day, for external treatments with a highly concentrated solution of 10 grams per 1 liter of water.
The treatment regimen was prescribed on the basis of anamnesis morbi and was 7 days for animals with gastrointestinal pathologies, 14 days with dermatological symptoms, which served as control time points in the study.
Dogs admitted to the hospital with a diagnosis of enteritis showed a decrease in the frequency of diarrhea and normalization of feces was noted on the third day of the supplement.
While dogs treated according to the standard regimen (antimicrobial sulfonamides), when the condition was normalized, showed signs of diarrhea for five days.
External treatment of the skin with a solution containing AI, gave effect the next day after application in the form of a reduction in hyperemia in the focus of inflammation and reduction of edema
In cats with gingivostomatitis, external treatments for 14 days also contributed to the reduction of signs of inflammation and appetite.
The conducted biochemical blood parameters of dogs showed approximately 50% increase in the concentration of tryptophan, kinureric acid and serotonin in the blood serum (tryptophan by 52.05%; kinureric acid by 43.17%; serotonin by 49.5%)
The use of IA in the treatment of the gastrointestinal tract pathologies of the skin is justified and recommended for use for cats and dogs. Supplement with IA has a good tolerance by the body of the animal, does not possess allergenic, mutagenic, teratogenic and irritant properties.
It can be used in all age groups of animals and has a wide spectrum of antimicrobial action.
To IA does not develop microbial resistance.
With local treatments, bacterial contamination of open extensive skin defects is reduced, which helps to reduce hyperemia, edema and tissue healing.
Increased serotonin concentration decreases sensitivity to stress factors, which results in less aggression.
The increased concentration of kinurerenic acid has an anti-inflammatory effect, which proves the claimed anti-inflammatory property of the additive.
Elevated levels of tryptophan indicate a positive effect on the metabolism of amino acids and, as a consequence, an increase in the bioavailability of feed components.