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The many faces aces of lawsonia intracellularis

The history of PIA

A high number of swine farms worldwide are facing porcine intestinal adenomatosis (PIA). Between 30-90% of the farms are thought to be infected, depending on the country. In North America, pig holders have been struggling with the infectious disease since the early 1990’s and it is estimated that it has caused yearly economic losses of 20 Mio. $. Due to intensive transnational trade, PIA has also spread to other countries and has now become increasingly important in Europe, causing problems in the UK, Denmark, Germany and Holland, to name only a few.

While the cause for the highly virulent enteric disease was unknown when it started to spread across wide regions of the USA, today the name and the nature of the causative pathogen is known: Lawsonia intracellularis, a gram-negative bacterium which is transmitted orally between pigs or through other animals, and which grows inside the cells of the small intestine. Due to this intracellular growth, Lawsonia intracellularis can remain hidden for a long time. Therefore, the contagion with the pathogen is possible from animals which don’t show clinical signs. which is one of the reasons why the disease is difficult to detect and prevent.

Not just PIA – the various appearances of lawsonia intracellularis infections

Even though the feared PIA is the most widely known manifestation of Lawsonia intracellularis, it is only one of its four clinical forms. Necrotic enteritis (NE), regional ileitis (RI) and PIA are the chronic courses of the disease, while proliferative haemorrhagic enteropathy (PHE) is the acute form of Lawsonia intracellularis. PHE, though very aggressive and often lethal, occurs less often than the chronic forms and is usually seen in finisher pigs of 6 months of age or older. It is most likely that increased stress during the end of the fattening period causes the pathogen to become virulent in previously subclinically infected animals.

The chronic manifestations of Lawsonia intracellularis are most often seen in piglets or in the early fattening period. The symptoms of these forms are less specific and include low feed intake and weight gain and different forms of diarrhea. A typical sign is also an increasing difference in body weight within the groups of animals of the same age. The mortality of affected groups is not very high, so that the economic problem of the disease is mainly due to low productivity of the fattening pigs. A definite identification of the chronic form which is affecting the animals, PIA, RI or NE, is only possible through post-mortem analysis of the intestine. The different forms affect different parts of the ileum and vary slightly in their appearance. However, the underlying pathogen, Lawsonia intracellularis, can also be determined in live animals through diagnostic detection in the faeces.

Can Lawsonia intracellularis be prevented?

As in all infectious diseases, a thorough hygiene protocol within the farm is a must. Booths should be cleaned and disinfected after each group of animals that passes through. Swine holders should make sure to use a disinfectant which is effective against Lawsonia intracellularis and manage their stables in a strict all-in-all-out routine.

Various antibiotics can be applied when Lawsonia intracellularis becomes clinical. For the chronic forms, a water application of antibiotics can be used, while PHE should be treated through injections of the affected animals. However, when Lawsonia intracellularis becomes acute, mortalities can rise to 50% or more, even with antibiotic treatment. Therefore, and due to the quick spread of Lawsonia intracellularis, prophylaxis is key. Anti-inflammatory substances can strengthen the animal. Since the disease often breaks out in times of increased stress, additives which reduce stress can also be a good way to support the pigs in combatting Lawsonia intracellularis.

About the author

Sophie-Charlotte Wall studied agricultural sciences at the University of Göttingen, specializing on animal sciences. She has gained practical experience in various species before focusing on swine production at Phytobiotics. Sophie's goal is to support a sustainable pig nutrition and improving animal performance and well-being through the functional application of high quality feed additives.

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